Thursday May 18 2006

8:30 - Registration and Welcome Address
Dr Marvin Edeas, President of the French Society of Antioxidants, Paris, France

9:00 - Economic Impact of Anti-Obesity Drugs

What marketshare do anti-obesity drugs have in France, in Europe and world wide?
What are the latest trends in the anti-obesity drug market?

Mrs Katia Musitu, IMS Health, London, UK

SESSION 1 : General Presentation of Obesity

9:30 - Obesity should be accepted as a disease
Definition, prevalence, pathogenesis

Classification of Obesity (degree, body fat distribution) - cut-off points
Epidemiological data
Pathogenesis
- Regulation of energy balance (genetic and neurohormonal factors: orexigenic and anorexigenic pathways)
- Role of genetic factors (rare monogenic and syndromic forms of obesity vs. common polygenic obesities)
- Role of environmental factors: positive energy balance as aresult of the high energy density diet and low physical activity and adoption of a sedentary lifestyle
- Nutrients in body weight reguation
- Gene - environment interaction and body weight change

Obesity Associated Diseases

Metabolic syndrome - definition, crucial role of abdominal obesity
Diseases:
- Metabolic: Type 2 diabetis mellitus, hyper/dyslipidaemia, hyperuricaemia, inflammatory response
- Cardiovascular: hypertension, coronary heart disease, stroke, endothelial dysfunction, thrombosis
- Other: Cancer, sleep apnoea, depression, unfertility, osteoarthritis, etc...

Pr Vojtech Hainer, Obesity Management Center, Endocrine Institute, Prague, Czech Republic.

10:00 - Break and Poster Session

10:30 - Childhood Obesity: First Step of a Future Epidemic ?
Review on the childhood Epidemic – still on the rise?
Risk factors childhood Obesity

Overview of Risk Factors
Moving the volatile point of the balance: the role of programming - maternal smoking in Pregnancy e.g.
Prevention
Who should be targeted? At risk strategy or whole population strategy?

11:00 - Obesity in animals
What are the animals concerned by obesity?
What are the differences or similarities with obesity in humans?
What are the different ways to manage this problem?
Christophe Blanckaert, Veterinary Clinic Les Margats, Boulogne sur Mer, France

11:30 - Role of Circadian Clock in the Management of Obesity?
What is the role of the clock gene in the circadian rhythmicity ?
What are the relationschips between the circadian clock and the fuel metabolims of the organism ?
What are the impacts of circadian clock disfunction on weight management ?
Dr Fred Turek, Northwestern University, Evanston, Illinois, USA

12:00 - What are the new scientific insights in the obesity field? 5 minutes to convince
Oral presentations selected upon abstract submission: for scientists, pharmaceutical laboratories, veterinarian health compagnies, food supplement companies and start-ups

12:30 - Lunch

SESSION 2: What are the strategies used to prevent and/or treat obesity ?

14:00 - Current Pharmacotherapies and New Drugs in Developpment
Appetite suppressors: example of Sibutramine. Mechanism of action, efficiency and side effects.
Metabolism modificators: example of Orlistat. Mechanism of action, efficiency and side effects.
New drugs in developpment: Axokine, Rimonabant and Bupropion SR.
Pr Olivier Ziegler,Hospital of Nancy, Toul, France

14:30 - Brain Regulation of Energy Metabolism
Wich parts of the central nervous system control hunger and energy expenditure?
How do these regions stay informed about the metabolic state of the body?
Which transmitters and, in particular, neuropeptides are involved?
Dr Christian Broberger, Department of neurosciences, Karolinska Institutet, Stockholm, Sweden

15:00 - Targeting the Lipid and Carbohydrate Metabolism
Inhibition of fatty acids absorption
Inhibition of adipogenesis and fat storage
Stimulation of enzymes involved in lipolysis
Dr Yuguang Shi, Hershey Medical Center, Penn State University,Hershey, Pennsylvania,USA

15:30 - Bariatric surgery
What are the different kind of bariatric surgeries? Gastroplasty, gastric bypass, biliopancreatic diversion, gastric banding
What efficiency for what risk? clinical data
Dr Jérôme Dargent, Policlinic of Rillieux, Rillieux-le-pape, France

16:00 - Break and Poster Session

SESSION 3: Impact of Nutrition and/or Nutraceutical in obesity Prevention and Treatment

16:30 - Dietary calcium intake, Dairy Products and Obesity: Overviw and Perspectives
What are the effects of calcium on body weight?
What are its mechanisms of action?
What is the impact of dairy product consumption on body weight?
What is more effective: calcium in diairy products or in food supplements?
Dr Michael Zemel, FACN, University of Tennessee, Knoxville, USA

16:50 - Beneficial effects of bile acids: a new way to treat obesity by food supplementation?
What are the physiological effects of cholic acid? (lowering of triglycerid levels, increasing energy expenditure)
Which are the mechanisms involved to product these effects?
Could food supplementation by cholic acid be an interesting way to treat obesity?
Dr Sander Houten, Laboratory Genetic Metabolic Diseases, University of Amsterdam, Amsterdam, The Netherlands

17:10 - Latest Advances, Clinical Studies and Scientific Credibility of Ingredient Supplemented Food in the Fight Against Obesity. (Examples of supplements: fibers, vegetal sterols, CLA, cinnamon, chromium and fenugreek)

17:40 - Round Table Discussion with the participation of multinationals food companies

What are the policies, strategies and initiatives of big food industries to fight against obesity?
What is the future of nutritional or natural ingredient supplemented food in the prevention of obesity?
What is the efficiency of these new products?
Which are the current and future products on the obesity market?

20:30 Gala Dinner

Friday May 19 2006

SESSION 4: New Targets for Therapies against Obesity

9:00 - Interesting Molecular Targets: the Peroxisome Proliferator-Activated Receptors (PPARs)
What is the connection between glucide and lipid metabolism
The different isoforms and their respective rôle in lipid and glucose homeostasis
Future directions for new therapies against obesity: example of PPAR-δ agonists
Pr Staels, University of Lille 2, Lille, France

9:30 - An RNAi-based Approach to Metabolic Disease
What is RNAi technology?
What are the different in vitro and in vivo steps to indentify a potential traget ?
What are the new targets identified by RNAi technology for obesity?
Pr Michael Czech, University of Massachusets, Worcester, USA

10:00 - Break and Poster Session

10:30 - Inflammation and Obesity: a new field for therapy?
What is the link between inflammation and obesity?
Inflammatory cytokines and oxidative stress: what role for antioxidant molecules?
What are the emerging pathways for the developpment of new therapies against obesity?
Dr Alain Géloën, University of Lyon 1, Lyon, France

11:00 - Role of Mitochondria and Uncoupling Proteins in Obesity and Insulin Secretion
Mitochondria and thermogenesis
Uncoupling proteins and insulin secretion
Uncouplig proteins: a new target to treat obesity?
Dr Cathy Chan, Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, Prince Edward, Canada.

11:30 - What are the potential new targets and useful pathways for new therapies against obesity? 5 minutes to convince.
Oral presentations selected upon abstract submission: for scientists, pharmaceutical laboratories, veterinarian health compagnies, food supplement companies and start-ups

12 :30 - Lunch

SESSION 5: Latest Advances on Natural Ingredients and Alternative Therapeutics against Obesity

14:00 - Conjugated Linoleic Acid (CLA): which isomer, toxicity and clinical data
Does CLA induce diabetes?
Dr Bernard Schmitt, CERN/CHBS, Lorient, France

14:30 - Potential Use of Natural Antioxidants in the treatment of Obesity
Inhibition of the oxidative stress vicious circle
How can antioxidants control mitochondria metabolism?
Which antioxidant can we use to treat obesity: green tea extract, lipoic acid, riboflavin and L-Carnitine
Dr Marvin Edeas, President of the French Society of Antioxidants, Paris, France

15:00 - Dietary Supplements and Body-Weight Reduction
What are the results of a systematic review of the literature about dietary supplements?
What is the impact of dietary supplements on body-weight reduction?
Pr Edzard Ernst, University of Exeter and Plymouth, Exeter, UK

15:30 Natural Appetite Suppressants: Reducing caloric intake in the natural way
Overview of the regulatory mechanism that controls appetite.
Latest innovations with a special focus on natural ingredients acting on gut hormones.
Efficiency and mechanism of action of an original ingredient derived from pine nuts
Dr Sandra Einerhand, Lipid Nutrition, Wormerveer, The Netherlands

16:00 - Break and Poster Session

16:30 - Point of View of a Medical Doctor: Which Natural ingredients could be efficient treatments of Obesity in medical everyday practice?
Green coffee beans, Ephedra, Fenugreek, Garcinia cambodgia, Guarana, Ispaghula, Konjac, Manganese, Nopal, Apple pectin, Phaseolus vulgaris, Phlorizin, Hieracium pilosella, calcium, potassium, chitosan.
Dr Paul Goetz, Strasbourg, France

17:00 - What are the latest innovations in the natural ingredients and natural products field to fight or prevent obesity? 5 minutes to convince.
Presentations selected upon abstract submission: for scientists, pharmaceutical laboratories, veterinarian health companies, food supplement companies and start-ups

If you want to present your innovation, please contact the scientific committee.

17:30 - Discussion and conclusion : What are the Perspectives for Anti-Obesity Therapies? What criteria should have the ideal molecule and the ideal strategy to treat and/or prevent obesity?
(In the Presence of the Scientific Committee)

Anti-Obesity Therapies 2006 Innovation Award
The scientific committee will name the most innovative project upon oral or poster presentation